We have a global team of experienced veterinarians that have now treated many thousands of cases. Please feel free to contact us to answer any questions on case selection and management, or the clinical application of Arthramid® Vet.
Method Of Administration
Arthramid® Vet is for intra-articular use only and must be administered by a qualified veterinarian familiar with the procedure in the intended species.
Animals may be sedated to minimise stress and discomfort. Strict aseptic conditions must be followed at all times.
A 20G to 23G needle is placed intra-articularly. Synovial fluid should be observed. Care should be taken to avoid unnecessary damage of the intra-articular tissue, as this may result in local swelling lasting for 24 to 48 hours. Remove the protective tip cap from the Arthramid® Vet syringe. Attach the syringe firmly into the Luer lock socket on the needle. Make sure the syringe is correctly mounted. The amount of Arthramid® Vet used is 1 – 4 mL. If necessary, attach a new Arthramid® Vet syringe during the procedure and continue the injection.
Post Injection Instructions
An ointment can be applied to the injection site immediately after treatment. A cold pack can be used on the injection site in case of any oedema. A bandage can be applied around the injection site if possible. Local or systemic corticosteroids should not be administered to the animal within two weeks of injection of Arthramid® Vet since this may mask a possible infection. The animal should be rested for 48 hours after the treatment.
Some animals (< 1: 1000) may develop pain within the first postoperative hours. In addition, there is also a slight risk of haematoma and mild oedema. Within 1-2 weeks after treatment, there is a small risk that the animal may develop transient oedema and tenderness at the treatment site as the tissue integration is occurring. If not caused by infection, these reactions are self-limiting and will resolve within a couple of weeks. Non-steroidal anti-inflammatory drugs (NSAIDs) can be administered for pain relief and to reduce swelling. Joint lavage to remove non-integrated hydrogel can be considered in severe cases. Allergic reactions to Arthramid® Vet have never been observed.
As with any intra-articular procedure, an Arthramid® Vet injection carries a risk of infection. Standard precautions and strict aseptic injection technique is essential. In the event of infection, the use of broad spectra antibiotics is recommended as a first-line treatment. Any use of corticosteroids is contraindicated in case of infection.
Dosage - Equine
Due to Arthramid® Vets’ unique mode of action, the following dosage recommendations have been made based on observed clinical responses to treatment.
- Distal Interphalangeal (DIP/ Coffin) 1 mls
- Metacarpo/tarso-phalangeal (Fetlock) 1-2 mls
- Carpus- 1-2mls
- Tarso-metatarsal (TMT)/ Distal-intertarsal (DIT)- 1 ml
- Tarsocrural- 2-3 mls
- Shoulder- 2-3 mls
- Stifles- 1-2 ml per compartment e.g 1- 2mls for medial-femorotibial joint.
There is evidence to suggest that a dose-dependant response does exist and that these doses can be altered depending on the severity or chronicity of the disease. For example; mild, moderate or severe fetlock disease can be treated with either 1ml, 2mls, or 3mls respectively.
It is always important to reassess cases 4-6 weeks after first treatment. Published clinical trials indicate horses that partially respond to initial treatment may benefit from a second dose at 4 to 6 weeks later. Repeated treatments outside this time period should be based on response to treatment and reoccurrence of clinical signs; typically 6 to 12 months, and up to 2-years in some cases.
Safety Studies indicate that concurrent treatment of multiple joints in the same animal is safe.