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Method Of Administration
Arthramid® Vet is for intra-articular use only and must be administered by a qualified veterinarian familiar with the procedure in the intended species.
Animals may be sedated to minimise stress and discomfort. Strict aseptic conditions must be followed at all times.
A 20G to 23G needle is placed intra-articularly. Synovial fluid should be observed. Care should be taken to avoid unnecessary damage of the intra-articular tissue, as this may result in local swelling lasting for 24 to 48 hours. Remove the protective tip cap from the Arthramid® Vet syringe. Attach the syringe firmly into the Luer lock socket on the needle. Make sure the syringe is correctly mounted. The amount of Arthramid® Vet used is 1 – 4 mL. If necessary, attach a new Arthramid® Vet syringe during the procedure and continue the injection.
Post Injection Instructions
An ointment can be applied to the injection site immediately after treatment. A cold pack can be used on the injection site in case of any oedema. A bandage can be applied around the injection site if possible. Local or systemic corticosteroids should not be administered to the animal within two weeks of injection of Arthramid® Vet since this may mask a possible infection. The animal should be rested for 48 hours after the treatment.
Some animals (< 1: 1000) may develop pain within the first postoperative hours. In addition, there is also a slight risk of haematoma and mild oedema. Within 1-2 weeks after treatment, there is a small risk that the animal may develop transient oedema and tenderness at the treatment site as the tissue integration is occurring. If not caused by infection, these reactions are self-limiting and will resolve within a couple of weeks. Non-steroidal anti-inflammatory drugs (NSAIDs) can be administered for pain relief and to reduce swelling. Joint lavage to remove non-integrated hydrogel can be considered in severe cases. Allergic reactions to Arthramid® Vet have never been observed.
As with any intra-articular procedure, an Arthramid® Vet injection carries a risk of infection. Standard precautions and strict aseptic injection technique is essential. In the event of infection, the use of broad spectra antibiotics is recommended as a first-line treatment. Any use of corticosteroids is contraindicated in case of infection.
Dosage - Equine
Due to Arthramid® Vets’ unique mode of action, the following dosage recommendations have been made based on observed clinical responses to treatment.
- Distal Interphalangeal (DIP/ Coffin) 1 mls
- Metacarpo/tarso-phalangeal (Fetlock) 1-2 mls
- Carpus- 1-2mls
- Tarso-metatarsal (TMT)/ Distal-intertarsal (DIT)- 1 ml
- Tarsocrural- 2-3 mls
- Shoulder- 2-3 mls
- Stifles- 1-2 ml per compartment e.g 1- 2mls for medial-femorotibial joint.
There is evidence to suggest that a dose-dependant response does exist and that these doses can be altered depending on the severity or chronicity of the disease. For example; mild, moderate or severe fetlock disease can be treated with either 1ml, 2mls, or 3mls respectively.
It is always important to reassess cases 4-6 weeks after first treatment. Published clinical trials indicate horses that partially respond to initial treatment may benefit from a second dose at 4 to 6 weeks later. Repeated treatments outside this time period should be based on response to treatment and reoccurrence of clinical signs; typically 6 to 12 months, and up to 2-years in some cases.
Safety Studies indicate that concurrent treatment of multiple joints in the same animal is safe.
Arthramid Vet should not be used in actively infected areas;
- Do not use in animals with acute/ chronic disease that are receiving concurrent treatment with systemic corticosteroids or antibiotics.
- Do not use if package is open or damaged.
- Do not resterilise Arthramid Vet.
- Do not inject Arthramid Vet intravascularly.